DEF 14A of Oric Pharmaceuticals, Inc., Apr 23, 2025

DEF 14A of Oric Pharmaceuticals, Inc.

Filed Apr 23, 2025 · FY20240001193125-25-091359

Open on EDGAR
  1. Nominees for Director

    Nominees for Director Steven L. Hoerter has served as a member of our board of directors since August 2021. From March 2019 to June 2024, Mr. Hoerter served as President and Chief Executive Officer of Deciphera Pharmaceuticals, Inc. (“Deciphera”), a commercial-stage public biotechnology company, when Deciphera was acquired by ONO Pharmaceutical. From February 2016 to March 2019, Mr. Hoerter served as the Chief Commercial Officer of Agios Pharmaceuticals, Inc., a public biotechnology company. From August 2011 to March 2015, Mr. Hoerter served as Senior Vice President, Commercial at Clovis Oncology, Inc., a biotechnology company, and from March 2015 to February 2016, he served as Chief Commercial Officer. Mr. Hoerter has served on the board of directors of C4 Therapeutics, Inc., a clinical-stage public biopharmaceutical company, since November 2024, and MBX Biosciences, a clinical-stage public biopharmaceutical company, since April 2025. Mr. Hoerter previously served on the board of directors of Deciphera from May 2018 until its acquisition by ONO Pharmaceutical in June 2024; Constellation Pharmaceuticals, Inc., a clinical-stage public biotechnology company, from September 2018 until its acquisition by MorphoSys AG in July 2021, and Ignyta, Inc., a publicly traded precision oncology company, from December 2016 until its acquisition by Roche Holding AG in February 2018. Mr. Hoerter holds a B.A. from Bucknell University, an M.B.A. from Tilburg University, and an M.S. in management from Purdue University. We believe that Mr. Hoerter is qualified to serve on our board of directors due to his global management and commercial experience in the biotechnology industry and his experience serving as a public company director. Angie You, Ph.D., has served as a member of our board of directors since November 2021. Since March 2023, Dr. You has served as Chief Executive Officer and member of the board of directors of Architect Therapeutics, LLC, a biotechnology company, and since February 2022, Dr. You has served as a senior advisor to Frasier Healthcare. From April 2022 to May 2023, Dr. You served as advisor to Casdin Capital. From December 2018 to January 2022, Dr. You served as Chief Executive Officer of Amunix Pharmaceuticals, Inc. (“Amunix”), an immuno-oncology company, when Amunix was acquired by Sanofi S.A. From September 2014 to December 2018, Dr. You served as Chief Business & Strategy Officer and Head of Commercial at Sierra Oncology, Inc., where she helped the company through a successful initial public offering and led the company’s strategic and transactional business and commercial efforts. Dr. You has served as a member of the board of directors of Candid Therapeutics, Inc. a biotechnology company, since October 2024 and as a member of the board of directors of Attovia Therapeutics, a biotechnology company, since July 2024. From April 2022 to March 2024, Dr. You served on the board of directors of RayzeBio, Inc, a biotechnology company. Dr. You holds an A.B. in Chemistry from Harvard College and a Ph.D. in Biochemistry from Harvard University. We believe that Dr. You is qualified to serve on our board of directors due to her drug development expertise and commercial strategy expertise in the biotechnology industry and her experience serving as a public company director.

  2. Continuing Directors

    Continuing Directors Richard Heyman, Ph.D., has served as a member of our board of directors since March 2015 and as Chairman of our board of directors since May 2018. Dr. Heyman also served as our President and Chief Executive Officer from November 2015 to May 2016 and as our Acting President and Chief Executive Officer from November 2017 to May 2018. Since 2019, Dr. Heyman has served as a venture partner for Arch Ventures, a venture capital firm. From August 2013 to April 2015, Dr. Heyman served as President and Chief Executive Officer of Seragon, which was acquired by Genentech in 2014. Prior to that, he served as Co-Founder, President and Chief Executive Officer of Aragon Pharmaceuticals, Inc., a biotechnology company that was acquired by Johnson & Johnson, a medical device, pharmaceutical and consumer packaged goods company, in 2013. Dr. Heyman currently serves on the board of directors of Architect Therapeutics LLC, a biotechnology company, since 2023, PMV Pharma since 2020, Vividion since 2018, and Enliven Therapeutics, a biotechnology company, since 2021. From June 2015 to March 2023, Dr. Heyman served on the board of directors and as Executive Chairman and Co-Founder of Metacrine, Inc., a biotechnology company. Dr. Heyman also served on the board of directors of Gritstone Bio, a biotechnology company, from 2016 to 2022, Yumanity Therapeutics, Inc., a biotechnology company, from 2016 to 2022, Amunix Pharmaceuticals Inc., a biotechnology company, from 2019 to 2021, and RayzeBio, Inc., a biotechnology company, from 2022 to 2024. He is Vice Chair of the Board of Trustees at the Salk Institute, on the Board Foundation for the American Association for Cancer Research and on the executive committee at the University of California at San Diego Moores Cancer Center. Dr. Heyman received a B.S. in chemistry from the University of Connecticut and a Ph.D. in pharmacology from the University of Minnesota. We believe that Dr. Heyman is qualified to serve on our board of directors because of his perspective having previously served as our President and Chief Executive Officer and more recently as our Acting President and Chief Executive Officer, his scientific background and his extensive career in the biotechnology industry. Lori Kunkel, M.D., has served as a member of our board of directors since June 2020. Since June 2016, Dr. Kunkel has been a principal and owner of LAK505, LLC, a biotechnology consulting company. Dr. Kunkel has served as a member of the board of directors, compensation committee, and development committee of Nurix Therapeutics, Inc., a private biotechnology company, since August 2019, as a member of the board of directors of K36 Therapeutics, Inc., a private biotechnology company, since December 2021, and as a member of the board of directors of Enliven Therapeutics, Inc., a biopharmaceutical company, since April 2024. Dr. Kunkel previously served on the board of directors of biotechnology companies Maverick Therapeutics, Inc., from January 2017 to April 2021, Loxo Oncology, Inc., from October 2014 to February 2019 and Tocagen Inc., from September 2015 to June 2020 (and as acting Chief Medical Officer from November 2018 to April 2019), and as a member of the board of directors, compensation committee, nominating and governance committee and development committee of Curis, Inc., a public biotechnology company, from November 2016 to September 2022, and several private companies. Dr. Kunkel received a B.A. from University of California, San Diego and an M.D. from University of Southern California. She is board certified in internal medicine and held board certifications in hematology and oncology. We believe that Dr. Kunkel is qualified to serve on our board of directors due to her medical and scientific background and her experience in the biotechnology industry. Jacob M. Chacko, M.D., has served as our Chief Executive Officer and as a member of our board of directors since May 2018 and as our President since May 2019. From May 2014 to February 2018, he served as Chief Financial Officer of Ignyta, Inc., a precision oncology company that was acquired in February 2018 by Roche Holding AG. From August 2008 to May 2014, Dr. Chacko served as Vice President at TPG Capital, a private equity investment firm. Prior to that, Dr. Chacko was a consultant to healthcare clients at McKinsey & Company, a management consulting firm. He has served as chair of the board of directors of Bright Peak Therapeutics, Inc., a private biotechnology company, since November 2021 and as a member of the board of directors of 4D Molecular Therapeutics, Inc., a public clinical stage biotechnology company, since March 2019. Dr. Chacko served on the board of directors of Turning Point Therapeutics, Inc., a public biotechnology company, from November 2018 to March 2021 and on the board of directors of Bonti, Inc. (“Bonti”), a private biotechnology company, from February 2018 to October 2018, when Bonti was acquired by Allergan plc. Dr. Chacko holds a B.A. in biology and B.S. in gerontology from the University of Southern California, an M.D. from University of California, Los Angeles, an M.B.A. from Harvard Business School and an M.Sc. from Oxford University. We believe that Dr. Chacko is qualified to serve on our board of directors because of the perspective and experience he provides as our President and Chief Executive Officer, as well as his broad experience within the biotechnology industry, particularly his financial, strategic and medical expertise. Mardi C. Dier has served as a member of our board of directors since February 2020. Ms. Dier has served as Chief Financial Officer of Madrigal Pharmaceuticals, Inc., a public biopharmaceutical company, since February 2024. From November 2022 to August 2023, Ms. Dier served as Chief Financial Officer and Chief Business Officer of ACELYRIN, Inc., a biotechnology company. From October 2020 to November 2022, Ms. Dier served as Executive Vice President and Chief Financial Officer of Ultragenyx Pharmaceutical Inc. Ms. Dier has served as Executive Vice President and Chief Financial Officer of Portola Pharmaceuticals from November 2013 through the acquisition by Alexion Pharmaceuticals in July 2020, as its Chief Business Officer from October 2018 and as a Senior Vice President and Chief Financial Officer from August 2006 to November 2013. From 2003 to 2006, Ms. Dier served as Vice President of Investor Relations at Chiron Corporation, a biotechnology company. From 1994 to 2001, Ms. Dier served as a Director, Investment Banking at Prudential Securities, Inc., a securities firm. Ms. Dier has served as a member of the board of directors and chair of the audit committee of Prelude Therapeutics, Inc., a clinical-stage precision oncology company, since August 2020, as a member of the board of directors of Synthekine, Inc., a biotechnology company, since May 2021, and as a member of the board of directors of Healthcare Royalty Partners, a healthcare investment firm, since December 2022. Ms. Dier served as a member of the board of directors and audit committee of Adamas Pharmaceuticals, Inc., a biotechnology company, from October 2017 to May 2021. Ms. Dier holds a B.S. in Biology from Stanford University and an M.B.A. from the Anderson Graduate School of Management at the University of California, Los Angeles. We believe Ms. Dier is qualified to serve on our board of directors because of her experience in the biotechnology industry and her extensive experience in finance and accounting.

  3. Considerations in Evaluating Director Nominees

    Considerations in Evaluating Director Nominees The nominating and corporate governance committee will consider candidates recommended by stockholders in the same manner as candidates recommended to the nominating and corporate governance committee from other sources. In its evaluation of director candidates, including the members of our board of directors eligible for re-election, the nominating and corporate governance committee will consider such factors as character, professional ethics and integrity, judgment, business acumen, proven achievement and competence in one’s field, the ability to exercise sound judgement, tenure on the board of directors and skills that are complementary to the board of directors, an understanding of ORIC’s business, an understanding of the responsibilities that are required of a member of the board of directors, other time constraints, diversity with respect to professional background, education, race, ethnicity, gender, age, geography and other individual qualities and attributes that contribute to the total mix of viewpoints and experience represented on the board of directors. The nominating and corporate governance committee evaluates these factors, among others, and does not assign any particular weighting or priority to any of these factors. The nominating and corporate governance committee may propose to our board of directors a candidate recommended or offered for nomination by a stockholder as a nominee for election to our board of directors. Additionally, the nominating and corporate governance committee may pay fees to third parties to assist in identifying or evaluating director candidates.

  4. Director Compensation

    Director Compensation Under our director compensation policy, each non-employee director receives the cash and equity compensation for board services described below. Our compensation committee has primary responsibility for reviewing and recommending to the board of directors for approval the compensation paid to non-employee directors. Our compensation committee reviews at least annually the type and form of compensation paid to our non-employee directors, which includes a market assessment and analysis by our independent compensation consulting firm, Aon’s Human Capital Solutions practice, a division of Aon plc (“Aon”), regarding practices at comparable companies. As part of this analysis, Aon reviews non-employee director compensation trends and data from companies comprising the same peer group used by our compensation committee in connection with its review of executive compensation. Based on this review, our compensation committee and board of directors consider adjustments to the non-employee director compensation program in effort to provide competitive compensation to our non-employee directors. In December 2023 and March 2024, our compensation committee, in consultation with Aon and based on Aon’s analysis of peer data, reviewed our director compensation policy and recommended to the board of directors, and the board of directors approved, an amendment to our director compensation policy to (i) increase the number of shares subject to the initial option award and annual option award to be made to our non-employee directors to 51,200 and 25,600, respectively, (ii) increase the cash compensation for service as a board member paid to our non-employee directors to $40,000, (iii) increase the cash compensation for service as chairperson of the nominating and corporate governance committee (iv) increase the cash compensation for service as a member of the nominating and corporate governance committee, and (v) change the date of grant for the annual option award made to our non-employee directors beginning in 2025. This amendment was approved to more closely align our director equity compensation practices with our comparable companies in an effort to continue to attract and retain non-employee directors. Additionally, the change in the date of grant beginning in 2025 was approved to align the grant date for our stock options with those of our executive and employee focal equity grants so that the exercise price for stock options across our Company is consistent. Furthermore, in December 2024, our compensation committee, in consultation with Aon and based on Aon’s analysis of peer data, reviewed our director compensation policy and recommended to the board of directors, and the board of directors approved the following changes to the Amended and Restated Director Compensation Policy effective for 2025 (the “2025 Amended and Restated Director Compensation Policy”): (i) increased the number of shares subject to the initial option award and annual option awards to be made to our non-employee directors to 70,000 and 35,000, respectively, and (ii) updated the definition of “change in control” to more closely align with the terms of our 2020 Equity Incentive Plan (the “2020 Plan”). The changes to the 2025 Amended and Restated Director Compensation Policy were approved with the same intent as 2024 changes, which was to provide market competitive compensation in order to attract and retain our highly skilled non-employee directors. Additionally, the update to the “change in control” language was approved to clarify that an individual who resigns as an employee of the Company to become a non-employee director does not receive the non-employee director acceleration rights with respect to equity awards granted prior to that individual becoming a non-employee director. The director compensation policy includes a maximum annual limit of $500,000 of cash compensation and equity awards that may be paid, issued or granted to a non-employee director in any fiscal year, increased to $750,000 in the fiscal year the non-employee director joins the board of directors as an outside director. For purposes of this limitation, the value of equity awards is based on the grant date fair value (determined in accordance with GAAP). Any cash compensation paid or equity awards granted to a person for their services as an employee, or for their services as a consultant (other than as a non-employee director), will not count for purposes of the limitation. Cash Compensation Non-employee directors are entitled to receive the following cash compensation for their services under the policy:

  5. Director Compensation

    | • | $40,000 per year for service as a board member; |

  6. Director Compensation

    | • | $40,000 per year for service as chairman of the board; |

  7. Director Compensation

    | • | $15,000 per year for service as chairperson of the audit committee; |

  8. Director Compensation

    | • | $7,500 per year for service as an audit committee member; |

  9. Director Compensation

    | • | $10,000 per year for service as chairperson of the compensation committee; |

  10. Director Compensation

    | • | $5,000 per year for service as a compensation committee member; |

  11. Director Compensation

    | • | $10,000 per year for service as chairperson of the nominating and corporate governance committee; and |

  12. Director Compensation

    | • | $5,000 per year for service as a nominating and corporate governance committee member. |

  13. Director Compensation

    Each non-employee director who serves as the chair of a committee shall not receive the additional annual cash fee as a member of the committee. The chairman of the board of directors shall receive the cash fee for service as chairman of the board in addition to the annual cash fee for service as a board member. All cash payments to non-employee directors are paid quarterly in arrears on a pro-rated basis. Equity Compensation Initial Option Award. Each person who first becomes a non-employee director will receive, on the date of the first board of directors or compensation committee meeting occurring on or after the date on which the person first becomes a non-employee director, an initial stock option award to purchase 51,200 shares of our common stock (increasing to 70,000 shares of our common stock effective as of December 12, 2024, as a result of the 2025 Amended and Restated Director Compensation Policy). The initial stock option award will vest as to 1/36th of the total number of shares on each monthly anniversary of the commencement of the individual’s service as a non-employee director, subject to the director’s continued service to us through the applicable vesting date. Annual Option Award. Each non-employee director automatically will receive, on the date that the Company’s executive officers are made focal equity grants in January of each year, an annual stock option award to purchase 25,600 shares of our common stock (increasing to 35,000 shares of our common stock effective as of December 12, 2024, as a result of the 2025 Amended and Restated Director Compensation Policy), except that the first annual stock option award received by an individual who becomes a non-employee director will be reduced by calculating the number as follows (x) 35,000 shares divided by (y) (1) the total number of fully completed months between the date the individual becomes a non-employee director and the date on which such annual stock option award is granted divided by (2) twelve (12) (rounded to the nearest whole share). Beginning January 1, 2025, the annual stock option award will vest as to 1/12th of the total number of shares on each monthly anniversary of the grant date of the annual stock option award, subject to the director’s continued service to us through the applicable vesting date. Annual stock option awards granted prior to January 1, 2025, will vest in full on the earlier to occur of the one-year anniversary of the grant of such annual stock option award or the business day prior to the next annual meeting of stockholders to occur following the date such award was granted, subject to the non-employee director’s continued service through the applicable vesting date. In the event of a “change in control” (as defined in our 2020 Plan), each non-employee director will fully vest in their outstanding company equity awards, including any initial stock option award or annual stock option award, immediately prior to the consummation of the change in control. All initial stock option awards and annual stock option awards will have an exercise price equal to the fair market value of a share of our common stock on the date of grant, and a maximum term of 10 years. The following table presents the total compensation each of our non-employee directors earned during the year ended December 31, 2024. Dr. Chacko was our only employee who served as a director during 2024 and did not receive any additional compensation for his services as a director. See the section titled “Executive Compensation” for information about Dr. Chacko’s compensation.

  14. Director Compensation

    | Name | Fees Earned or Paid in Cash ($) | Option Awards ($)(1) | Total ($) | | Richard Heyman, Ph.D.(2) | 100,000 | 146,150 | 246,150 | | Mardi C. Dier(3) | 60,000 | 146,150 | 206,150 | | Steven L. Hoerter(4) | 52,500 | 146,150 | 198,650 | | Lori Kunkel, M.D.(5) | 45,000 | 146,150 | 191,150 | | Angie You, Ph.D.(6) | 52,500 | 146,150 | 198,650 |

  15. Director Compensation

    | (1) Consists of grants made in 2024 to the Company’s non-employee directors pursuant to the annual stock option award and a director retention stock option award. The amounts disclosed represent the aggregate grant date fair value of the award as calculated in accordance with ASC 718. These amounts do not correspond to the actual value that may be recognized by the directors upon vesting of the applicable awards. For a discussion of how we calculate stock-based compensation expense, see Note 9 to the Financial Statements included in our Annual Report on Form 10-K filed on February 18, 2025. |

  16. Director Compensation

    | (2) As of December 31, 2024, Dr. Heyman held outstanding option awards covering 198,103 shares. |

  17. Director Compensation

    | (3) As of December 31, 2024, Ms. Dier held outstanding option awards covering 149,675 shares. |

  18. Director Compensation

    | (4) As of December 31, 2024, Mr. Hoerter held outstanding option awards covering 129,633 shares. |

  19. Director Compensation

    | (5) As of December 31, 2024, Dr. Kunkel held outstanding option awards covering 124,440 shares. |

  20. Director Compensation

    | (6) As of December 31, 2024, Dr. You held outstanding option awards covering 124,508 shares. |

  21. ELECTION OF DIRECTORS

    ELECTION OF DIRECTORS Our board of directors is currently composed of six (6) members. In accordance with our certificate of incorporation, our board of directors is divided into three classes with staggered three-year terms. At the Annual Meeting, two Class II directors will be elected for a three-year term to succeed the same class whose term is then expiring. Each director’s term continues until the election and qualification of such director’s successor, or such director’s earlier death, resignation, or removal. Any increase or decrease in the number of directors will be distributed among the three classes so that, as nearly as possible, each class will consist of one-third of our directors. This classification of our board of directors may have the effect of delaying or preventing changes in control of our company.

  22. Summary Compensation Table

    Summary Compensation Table The following table sets forth information regarding the compensation of our named executive officers for the years ended December 31, 2024 and December 31, 2023:

  23. Summary Compensation Table

    | Name and Principal Position | Year | Salary ($) | Bonus ($) | Stock Awards ($) | Option Awards ($)(1) | Non-Equity Incentive Plan Compensation ($)(2) | All Other Compensation ($) | Total ($) | | Jacob M. Chacko, M.D. | 2024 | 627,333 | — | 776,900 | 3,466,878 | 396,800 | 14,904(3) | 5,282,815 | | President and Chief Executive Officer | 2023 | 596,083 | — | 396,000 | 1,796,080 | 350,200 | 14,720(4) | 3,153,083 | | Dominic Piscitelli | 2024 | 458,083 | — | 274,200 | 1,223,604 | 210,800 | 15,272(5) | 2,181,959 | | Chief Financial Officer | 2023 | 435,584 | — | 144,000 | 651,079 | 204,800 | 14,358(6) | 1,449,821 | | Pratik Multani, M.D. | 2024 | 493,583 | — | 274,200 | 1,223,604 | 227,100 | 14,904(7) | 2,233,391 | | Chief Medical Officer | 2023 | 476,500 | — | 144,000 | 651,079 | 224,000 | 14,720(8) | 1,510,299 |

  24. Summary Compensation Table

    | (1) With respect to the option awards in 2024 and 2023, the amounts disclosed represent the aggregate grant date fair value of the award as calculated in accordance with ASC 718. All options are also subject to vesting acceleration under certain circumstances as more fully described in the section titled “—Potential Payments Upon Termination or Change in Control.” The amounts in this column do not correspond to the |

  25. Summary Compensation Table

    | actual value that may be recognized by the named executive officers upon vesting of the applicable awards. For a discussion of how we calculate stock-based compensation expense, see Note 9 to the Financial Statements included in our Annual Report on Form 10-K filed on February 18, 2025. |

  26. Summary Compensation Table

    | (2) The 2024 amounts reported represent cash bonuses earned under our 2024 bonus plan based upon the achievement of company objectives for the year ended December 31, 2024, which were paid in 2025. The 2023 amounts reported represent cash bonuses earned under our 2023 bonus plan based upon the achievement of company objectives for the year ended December 31, 2023, which were paid in 2024. Our bonus plans are more fully described below under the section titled “—Non-Equity Incentive Plan Compensation.” |

  27. Summary Compensation Table

    | (3) The amounts reported represent $13,800 in 401(k) plan matching contributions, $504 for life insurance premiums, and $600 for annual wellness per diem. |

  28. Summary Compensation Table

    | (4) The amounts reported represent $13,200 in 401(k) plan matching contributions, $558 for life insurance premiums, $600 for annual wellness per diem, and $362 for a five-year anniversary payment. |

  29. Summary Compensation Table

    | (5) The amounts reported represent $13,800 in 401(k) plan matching contributions, $504 for life insurance premiums, $600 for annual wellness per diem, and $368 for a five-year anniversary payment. |

  30. Summary Compensation Table

    | (6) The amounts reported represent $13,200 in 401(k) plan matching contributions, $558 for life insurance premiums, and $600 for annual wellness per diem. |

  31. Summary Compensation Table

    | (7) The amounts reported represent $13,800 in 401(k) plan matching contributions, $504 for life insurance premiums, and $600 for annual wellness per diem. |

  32. Summary Compensation Table

    | (8) The amounts reported represent $13,200 in 401(k) plan matching contributions, $558 for life insurance premiums, $600 for annual wellness per diem, and $362 for a five-year anniversary payment. |

  33. Outstanding Equity Awards at Fiscal

    Outstanding Equity Awards at Fiscal

  34. Potential Payments upon Termination or Change in Control

    Potential Payments upon Termination or Change in Control We adopted a Change in Control and Severance Policy, or our Severance Policy, pursuant to which our named executive officers and certain other key employees are eligible to receive severance benefits, as specified in and subject to the employee signing a participation agreement under our Severance Policy. This Severance Policy was developed with input from Aon regarding severance practices at comparable companies. It is designed to attract, retain and reward senior level employees. Each of our named executive officers signed a participation agreement under our Severance Policy providing for the rights to the applicable payments and benefits described below. The Severance Policy is in lieu of any other severance payments and benefits to which our named executive officers and key employee were entitled prior to signing the participation agreement under the Severance Policy. In the event of a termination of the employment of a named executive officer by the named executive officer for “good reason” or by us for a reason other than “cause,” death or “disability” (as such terms are defined in our Severance Policy), in each case, that occurs outside a period beginning on a “change in control” (as defined in our Severance Policy) and ending twelve months following a change in control (such period, the “change in control period”), then the named executive officer will be entitled to, in addition to any accrued benefits, the following payments and benefits:

  35. Potential Payments upon Termination or Change in Control

    | • | payment of his base salary as in effect immediately prior to his termination of employment for a period of nine months (twelve months, in the case of Dr. Chacko) following his termination date; |

  36. Potential Payments upon Termination or Change in Control

    | • | continuing payments equal to the monthly premium cost of continued health coverage under COBRA, for him and his eligible dependents for a period of up to nine months (twelve months, in the case of Dr. Chacko) if he timely elects COBRA coverage, or a taxable lump sum payment in lieu thereof equal to nine months (twelve months, in the case of Dr. Chacko) of such premiums; and |

  37. Potential Payments upon Termination or Change in Control

    | • | in the case of Dr. Chacko only, acceleration of vesting of his then outstanding time-based equity awards that would have become exercisable had he continued to be employed for an additional twelve months following the date of his termination of employment. |

  38. Potential Payments upon Termination or Change in Control

    In the event of a termination of the employment of a named executive officer by the named executive officer for “good reason” or by us for a reason other than “cause,” death or “disability,” in each case, that occurs within the change in control period, then the named executive officer will be entitled to, in addition to any accrued benefits, the following payments and benefits:

  39. Potential Payments upon Termination or Change in Control

    | • | a lump sum payment equal to twelve months (eighteen months, in the case of Dr. Chacko) of the named executive officer’s annual base salary as in effect immediately prior to the named executive officer’s termination of employment; |

  40. Potential Payments upon Termination or Change in Control

    | • | a lump sum payment equal to 100% (150%, in the case of Dr. Chacko) of the named executive officer’s target annual bonus for the year in which the named executive officer’s termination of employment occurred; |

  41. Potential Payments upon Termination or Change in Control

    | • | continuing payments equal to the monthly premium cost of COBRA, for a period of up to twelve months (eighteen months in the case of Dr. Chacko) if he timely elects COBRA coverage, or a taxable lump sum payment in lieu thereof equal to twelve months (eighteen months, in the case of Dr. Chacko) of such premiums; and |

  42. Potential Payments upon Termination or Change in Control

    | • | all unvested shares subject to then-outstanding equity awards held by each named executive officer will accelerate in full and, in the case of performance-based awards, all performance goals will be deemed achieved at 100% unless otherwise set forth in his award. |

  43. Potential Payments upon Termination or Change in Control

    The receipt of the payments and benefits provided for under the Severance Policy described above is conditioned on the named executive officer signing and not revoking a separation and release of claims agreement and such release becoming effective and irrevocable no later than the 60th day following the named executive officer’s termination of employment. If any of the payments or benefits provided for under the Severance Policy or otherwise payable to a named executive officer would constitute “parachute payments” within the meaning of Section 280G of the Code and could be subject to the related excise tax, the named executive officer will receive either full payment of such payments and benefits or such lesser amount that would result in no portion of the payments and benefits being subject to the excise tax, whichever results in the greater amount of after-tax benefits to them. We are not obligated to provide any tax gross-up payments to our named executive officers.