DEF 14A of Fennec Pharmaceuticals Inc., Apr 25, 2025

DEF 14A of Fennec Pharmaceuticals Inc.

Filed Apr 25, 2025 · FY20240001558370-25-005563

Open on EDGAR
  1. Election of Directors

    Election of Directors The number of directors of Fennec to be elected at the Meeting is six (6). The following are the names of the persons for whom it is intended that votes will be cast for their election as directors of the Corporation pursuant to the proxy which is hereby solicited, unless the Shareholder directs therein otherwise: Dr. Khalid Islam Mr. Chris A. Rallis Dr. Marco Brughera Dr. Jodi Cook Mr. Jeff Hackman Mr. Rostislav Raykov The term of office for each such person will be until Fennec’s next annual meeting of Shareholders or until such person’s successor is elected or duly appointed. In the event that prior to the Meeting any vacancies occur in the slate of nominees submitted above, it is intended that discretionary authority shall be exercised to vote the proxy hereby solicited (unless otherwise directed as aforesaid) for the election of any other person or persons as directors. Fennec management is not now aware that any of such nominees would be unwilling to serve as a director if elected. The Board unanimously recommends that Shareholders vote FOR the election of the above-named director nominees. The persons named in the enclosed form of proxy will vote FOR the election of each of the director nominees to hold office until the close of the next annual meeting of Shareholders, unless a Shareholder has specified in the proxy that his or her Common Shares are to be withheld from voting in respect thereof. Fennec has adopted a majority voting policy in director elections that will apply at any meeting of Shareholders where an uncontested election of directors is held. Pursuant to this policy, if the number of proxy votes withheld from a particular director nominee is greater than the votes for such director, the director nominee will be required to submit his or her resignation as a director to the Chair of the Board promptly following the applicable Shareholders’ meeting. Following receipt of resignation, the Governance and Nominating Committee will consider whether or not to accept the offer of resignation and make a recommendation to the Board. Within 90 days following the applicable Shareholders’ meeting, the Board shall publicly disclose in a news release their decision whether to accept the applicable director’s resignation or not, including the reasons for rejecting the resignation, if applicable. The Board shall accept the resignation absent exceptional circumstances. A director who tenders his or her resignation pursuant to this policy will not be permitted to participate in any meeting of the Board or the Governance and Nominating Committee at which the resignation is considered. A copy of the majority voting policy may be found on the Fennec website at www.fennecpharma.com. The following table sets forth the name of each of our executive officers and directors, such person’s principal occupation or employment, all other positions with Fennec and any significant affiliate thereof now held by such person, if any, the year in which such person became a director of Fennec and such person’s age. The Corporation has an Audit Committee, a Compensation Committee, and a Governance and Nominating Committee. The current members of such committees are noted below.

  2. Election of Directors

    | | | | | | Options to | | | | Current Principal Occupation | | Common | Acquire | | Name and Province/State and | | and Principal Occupation for | Director | Shares | Common | | Country of Residence, Position | Age | Previous Five Years | Since | Held | Shares | | Jeff Hackman, Massachusetts, USA Chief Executive Officer, Director | 63 | CEO and Director of Fennec Pharmaceuticals; Chairman and CEO of Comera Life Sciences; director and CEO of Legacy Comera | August 2024 | — | 450,000 | | Rostislav Raykov, New Jersey, USA Former Chief Executive Officer, Director | 49 | Director and Former CEO of Fennec Pharmaceuticals | July 2009 | 61,156 | 1,675,000 | | Robert Andrade, California, USA Chief Financial Officer | 50 | CFO of Fennec Pharmaceuticals | N/A | 134,675 | 606,549 | | Pierre Sayad, Texas, USA Chief Medical Officer | 50 | Chief Medical Officer of Fennec Pharmaceuticals; Chief Operating Officer and interim Chief Medical Officer at Zephyr Labz | N/A | — | 150,000 | | Chris A. Rallis, North Carolina, USA Director(1)(2)(3) | 71 | Executive in-residence at Pappas Capital; previously, CEO of ImmunoBiosciences | August 2011 | 53,020 | 182,706 | | Dr. Marco Brughera, Milano, Italy Director(1)(2)(3) | 69 | Former Group CEO of Leadiant Biosciences SpA; previously Global Head Rare Disease and R&D at Sigma-tau; VP Preclinical Development at Nerviano Medical Sciences. | August 2016 | — | 195,545 | | Dr. Khalid Islam, Lugano, Switzerland Chairman of Board, Director(1) | 69 | Founder and Chairman of Gain Therapeutics ; previously Chairman and CEO of Gentium S.p.A.; previously CEO of Arpida AG | April 2014 | 213,825 | 200,000 | | Jodi A. Cook, PhD South Carolina, USA, Director(2)(3) | 57 | CEO of Skylark Bio Inc, Former SVP, Head of Gene Therapy Strategy PTC Therapeutics, Inc, Former COO Agilis Biotherapeutics, Former Assistant Professor of Audiology Mayo Clinic | September 2019 | — | 120,000 |

  3. Election of Directors

    | (1) Member of the Audit Committee |

  4. Election of Directors

    | (2) Member of the Compensation Committee |

  5. Election of Directors

    | (3) Member of the Governance and Nominating Committee |

  6. Jeff Hackman

    Jeff Hackman Mr. Hackman, age 63, has served as a director and Chief Executive Officer of Fennec since August 2024. Mr. Hackman served as Chief Executive Officer and as Chairman of the board of directors for Comera Life Sciences and Legacy Comera from May of 2022 and September of 2021, respectively, through August 2024. Prior to joining Legacy Comera, he was President of U.S. Operations from 2019 to 2021 for EUSA Pharma, a global pharmaceutical company focused on cancers and rare diseases. Previously, from 2017 to 2018, Mr. Hackman filled several roles at Aegerion Pharmaceuticals Inc., a biopharmaceutical company, finishing as acting CEO of its parent company, Novelion Therapeutics Inc. (NVLNF). Under his leadership, Novelion reached profitability. He joined Novelion from Shire Inc., a biopharmaceutical company, where he had been Senior VP and Head of U.S. Internal Medicine / Oncology Franchise from 2016 to 2017. Previously, he established the North American oncology commercial division for Baxalta, a biopharmaceutical company, following two years leading US commercial operations for Sigma Tau, a research-based pharmaceutical company. He has also held senior roles in several other pharmaceutical companies. We believe that Mr. Hackman is well qualified to serve as our Chief Executive Officer and as a director due to his extensive industry experience in senior management and leadership positions.

  7. Rostislav Raykov

    Rostislav Raykov Mr. Raykov, age 49, has served as a director of Fennec since July 2009 and was Chief Executive Officer since July 2009 through to August of 2024. From January 2006 to December 2007, Mr. Raykov was a portfolio manager for Alchem Investment Partners and John Levin & Co. Prior to founding Alchem, Mr. Raykov was a portfolio manager and securities analyst for John A. Levin & Co. Event Driven Fund (2002-2005). Prior to joining John A. Levin & Co., Mr. Raykov was a securities analyst for the Merger Fund at Tiedemann Investment Group (1999-2002) and an investment banking analyst at Bear Stearns (1998-1999). Mr. Raykov earned a B.S. in Business Administration from the University of North Carolina at Chapel Hill. As a result of these and other professional experiences, Mr. Raykov has financial expertise and experience with the Corporation as it has developed within the drug development industry and, as such, is able to provide the Corporation with unique insight and guidance. Robert Andrade Mr. Andrade, age 50, has served as Chief Financial Officer since November 2015. Mr. Andrade was previously Chief Financial Officer and Director of Fennec from September 2009 until August 2013. In addition to his role with Fennec, Mr. Andrade was a private investor in 2015, and a senior analyst at Magnetar Capital from 2013 - 2014. Mr. Andrade graduated from University of Southern California, where he earned a Masters of Arts degree and Bachelor of Arts degree in economics.

  8. Dr. Pierre Sayad

    Dr. Pierre Sayad Dr. Sayad, age 50, is an accomplished biopharmaceutical executive with more than 22 years of proven success building and leading world-class organizations. During his tenure in the industry, Dr. Sayad has launched nine novel drugs across 14 therapeutic areas, including oncology (both solid tumors and hematologic malignancies) and neuroscience (depression, schizophrenia, bipolar and attention-deficit/hyperactivity disorder). Trained as a molecular physiologist, Pierre has been heavily involved in the successful commercial launches of several drugs, including oncology drugs at Onyx Pharmaceuticals, Karyopharm Therapeutics, Oncopeptides, and CTI BioPharma, and Eli Lilly and Company’s blockbuster neuroscience drugs. Pierre most recently served as chief operating officer and interim chief medical officer at Zephyr Labz. He also held senior leadership positions at the International Myeloma Foundation and Campbell Alliance. Dr. Sayad is a graduate of the School of Medicine, Loma Linda University, as well as Harvard Business School. Chris A. Rallis Mr. Rallis, age 71, has served as a director of Fennec since August 2011. Mr. Rallis has been an executive-in-residence at Pappas Capital, a life science venture capital firm since January 2008. Previously, Mr. Rallis was the President and Chief Executive Officer of ImmunoBiosciences, Inc. (“IBI”), a vaccine technology company formerly located in Raleigh, North Carolina from April 2006 through June 2007. Prior to joining IBI, Mr. Rallis served as an executive in residence (part-time) for Pappas Capital, and as a consultant for Duke University and Panacos Pharmaceuticals, Inc. Mr. Rallis is the former President and Chief Operating Officer (“COO”) and director of Triangle Pharmaceuticals, Inc., which was acquired by Gilead Sciences in January 2003 for approximately $465 million. Prior to assuming the role of President and COO in March 2000, he was Executive Vice President, Business Development and General Counsel. While at Triangle, Mr. Rallis participated in 11 equity financings generating gross proceeds of approximately $500 million. He was also primarily responsible for all business development activities which included a worldwide alliance with Abbott Laboratories and the in-licensing of ten compounds. Before joining Triangle in 1995, Mr. Rallis served in various business development and legal management roles with Burroughs Wellcome Co. over a 13 year period, including Vice President of Strategic Planning and Business Development. Mr. Rallis also serves on the board of Lung Cancer Initiative of NC, located in Raleigh, North Carolina. Mr. Rallis received his A.B. degree in economics from Harvard College and a J.D. from Duke University. As a result of these and other professional experiences, Mr. Rallis possesses particular healthcare industry knowledge and experience which strengthens the Board’s collective qualifications, skills, and experience. Dr. Marco Brughera Dr. Brughera, age 69, has been a director of Fennec since August 2016. Currently, he is the founder at Brucon srls and Strategic Advisor at Essetifin. From 2011 until 2021, Dr. Brughera had been CEO of Lediant Biosciences and has held several positions for the Sigma-Tau Group, including CEO and Global Head of Sigma Tau Rare Disease, President of Sigma-Tau Research and President of Sigma-Tau Pharmaceuticals. He drove the commercial revival of a lead oncology product line resulting in its successful sale for a total of around $900M. He also successfully out-licensed the Defibrotide US rights to Jazz Pharmaceuticals and the product Recovi to Chiesi Pharmaceuticals.. From 2004 to 2010, Dr. Brughera served as the Vice President of Preclinical Development at Nerviano Medical Sciences (NMS), a pharmaceutical oncology-focused integrated discovery and development company. He also served as the Managing Director at Accelera, an independent contract research organization with the NMS Group. From 1999 to 2004, Dr. Brughera held several senior level positions in the areas of research and development with Pharmacia and Pfizer. Prior to 1999, he held various positions at Pharmacia & Upjohn and Farmitalia Carlo Erba SpA, an Italian pharmaceutical company. He currently serves on the Board of Leadiant Biosciences Inc and Limited; advisor and biotech champion at Indaco Ventures Partners SGR. Previously was a Board member of Gentium, Exelead, Soligenix, Lee’s Pharmaceuticals and Naicons. Dr. Brughera earned his degree in veterinary medicine from the University of Milan and is a European Registered Toxicologist. Dr. Brughera has wide-spread experience and knowledge of pharmaceutical drug development in international companies. His scientific and business knowledge in particular in the oncology and orphan drug space deepens the board’s collective qualifications, skills and experience.

  9. Dr. Khalid Islam

    Dr. Khalid Islam Dr. Islam, age 69, has been a director of Fennec since April 2014 and is our current Chairman of the Board. Dr. Islam was the Chairman and CEO of Gentium S.p.A. (a Nasdaq-listed company; 2009-2014) where he led the transition from a loss-making to a cash-flow positive and profitable company. Under his leadership, the company value increased from US$25 million leading to a successful all cash US$1 billion merger with Jazz Pharmaceuticals, plc. Subsequent to the sale of Gentium, Dr. Islam has been involved from both an advisory and board level in several public and private healthcare related companies. From 1999-2008, Dr. Islam was President and CEO of Arpida AG where he transitioned the early-stage start-up to a SWX-listed company and raised US$300 million in the IPO and follow-ons. From 1987-1999, he held various positions in HMR & MMD (now Sanofi-Aventis). From 1977-1987, Dr. Islam worked in academia at Imperial College (Univ. of London) and in Milan University, where he was a contract professor. Dr. Islam is a graduate of Chelsea College and received his Ph.D. from Imperial College, University of London. He holds several patents and has published over 80 articles in leading journals. He is an advisor to the venture group Kurma Biofund (Paris). He is a founder/co-founder of Gain Therapeutics Inc. (GANX), Sirius Healthcare Partners GmbH (Zurich), PrevAbr LLC (D.C.), BioAim LLC (L.A.) & Life Sciences Management GmbH (Zug). Dr. Islam is Board Chair at Minoryx Therapeutics (Spain) and Gain Therapeutics Inc. (GANX), a public company. In the past, he has served on the Board of Directors of Immunomedics (USA), Processa Pahramacueticals (PCSA), Pcovery Aps (Denmark), Adenium Aps (Denmark), C10 Pharma AS (Norway), Karolinska Development (KDEV, Sweden) and MolMed S.p.A. (MLMI, Italy). Dr. Islam’s extensive international pharmaceutical expertise in transitioning companies from development to production strengthens the Board’s collective qualifications, skills and experience. Dr. Jodi Cook Dr. Cook, age 57, has been a director of Fennec since September 2019. Dr. Cook is currently CEO of Skylark Bio Inc, an early-stage Company working on gene therapy for genetic disorders. Dr. Cook previously served as SVP and Head of Gene Therapy Strategy at PTC Therapeutics from August 2018 until February 2020. Previously she was one of the founding members and Chief Operating Officer of Agilis Biotherapeutics, a clinical-stage company focused on gene therapies for rare diseases of the central nervous system, from December 2013 until its acquisition by PTC Therapeutics in August 2018. While at Agilis she led the sale of the company to PTC in a deal that represented significant value to all parties. Dr. Cook’s career spans a wide range of experiences including VP of Clinical Research at InSound Medical and Director of Audiology at Songbird Hearing, both successful biotech start-up companies within the hearing industry. She has been Assistant Professor of Audiology and Director of the Hearing Aid Program at Mayo Clinic. Dr. Cook earned a BA from Loyola University in Maryland, M.Aud. from University of South Carolina, and PhD from Arizona State University in Hearing Science. She completed a clinical fellowship at Johns Hopkins School of Medicine in Baltimore, MD. Her extensive scientific, clinical and executive business experience strengthens the Board’s collective qualifications, skills and expertise.

  10. Compensation Discussion and Analysis

    Compensation Discussion and Analysis This discussion relates to the Named Executive Officers listed in the Summary Compensation Table below. Mandate of the Compensation Committee It is the task of the Compensation Committee to periodically review Fennec’s compensation structure with respect to its Named Executive Officers, including its Chief Executive Officer, to ensure that Fennec continues to attract and retain qualified and experienced individuals to its management team and to motivate these individuals to perform to the best of their ability and in Fennec’s best interests. The Compensation Committee determines the compensation of the Named Executive Officers, evaluates and approves the compensation plans, policies and programs of the Corporation and recommends to the Board from time to time other incentive compensation plans that it determines should be considered. In reviewing executive compensation, the Compensation Committee relies on the advice of the Chief Executive Officer regarding other executive officers and allows him to participate in the Committee’s deliberations on those executive officers. The Chief Executive Officer, however, is not allowed to participate in the Committee’s deliberations on his compensation. The Compensation Committee may not delegate any of its responsibilities to another entity or to an individual without the approval of the Board. General Compensation Philosophy The key components of executive officer compensation are salaries, cash incentive awards and equity inventive awards. Fennec’s policy with respect to the compensation of Named Executive Officers is to establish annual goals with respect to corporate development and the individual areas of responsibility of each Named Executive Officers and then to review total compensation with respect to the achievement of these goals. Salary and Non-Equity Incentive Awards It is Fennec’s policy that the base salaries paid to its Named Executive Officers reflect, in addition to the criteria set out above, the individual’s responsibility, experience and achievements. Further, base salary, which forms the basis for attracting talent and remaining competitive with the market, is also determined in consideration of market rates for similar positions. In this regard, Named Executive Officers’ cash compensation represents the 50% percentile mark among Fennec’s comparators (20 companies). Each year the Compensation Committee sets a series of objectives for each executive and for the executive team as a whole to determine the opportunity for cash incentive awards. These objectives are prioritized and assigned potential values in light of overall company objectives, including with respect to scientific, clinical, regulatory, intellectual property, business and corporate development, and financial objectives. The Compensation Committee reviews both base salaries and cash incentive awards on at least an annual basis to ensure that the relevant criteria are satisfied. See “2024 Short Term Incentives” below. Fennec also provides change in control cash benefits to Named Executive Officers. The primary rationale of our change in control cash benefit program is to provide sufficient employment and income protection so that our top executives will consider, and even seek out, corporate transactions that are in the best interest of shareholders, regardless of whether those transactions jeopardize their own employment. We believe the existing change in control benefits to the CEO and CFO, together with their equity awards, encourage such value-driving strategic activity. See “Payments on Change of Control” below. Equity Incentives - Stock Options and RSUs The annual compensation considerations also include the awarding of stock options, restricted stock units (“RSUs”) and other equity awards. The granting of options and RSUs to the Named Executive Officers under the Equity Incentive Plan serves three primary purposes: (1) to recognize significant performance during the past year; (2) to provide long-term incentives for future efforts, since the value of the options is directly dependent on the market valuation of the Corporation; and (3) to retain individuals, as the options and RSUs typically vest over time and, in some cases, upon the achievement of certain events, such as regulatory approval. When determining whether and how many new option or RSU awards will be made, the Compensation Committee takes into account the amount and terms of any outstanding options and RSUs. The Compensation Committee generally considers the granting of options and RSUs twice annually to all eligible employees, including executive officers. The Committee, in its discretion, may grant options, RSUs or other equity awards at other times during a fiscal year to a Named Executive Officer for performance or other reasons. See “2024 Equity Awards” below. Fennec does not require its Named Executive Officers to own a specific number of Common Shares. None of Fennec’s current executive team or board members are company founders and, until relatively recently, Fennec’s cash compensation packages for executives and board members has been comparatively low and insufficient to generate wealth in keeping with meaningful share ownership requirements. Historically, Fennec has also not had equity programs conducive to assisting executives and board members in achieving any prescribed ownership levels. Fennec is proposing to introduce, subject to shareholder approval at the Meeting, an employee share purchase program to encourage employees of the Corporation and its subsidiaries (including Named Executive Officers) to acquire and hold Common Shares. See: “Special Business – Amendments to Equity Incentive Plan” above. Analysis of Named Executive Officer Compensation The Compensation Committee is charged with annually reviewing and approving corporate goals and objectives relevant to each of the Named Executive Officer’s compensation, evaluating each officer’s performance in light of those goals and objectives, and fixing and determining each Named Executive Officer’s level of salary and award of cash incentive payments and options based on this evaluation. In determining the long-term incentive component of each Named Executive Officer’s compensation, the Compensation Committee considers the Corporation’s performance and relative shareholder return, the value of similar incentive awards to other similarly situated executive officers at companies in the peer group, the awards given to the Named Executive Officer in past years, and such other factors as the Compensation Committee considers relevant. The Compensation Committee’s review and evaluation includes measurement of the following areas:

  11. Compensation Discussion and Analysis

    Every Named Executive Officer had a maximum short term incentive award cap in 2024, based on a percentage of such executive’s base salary. These caps were 50% for Mr. Raykov and Mr. Hackman, and 40% for Mr. Andrade. All payouts of earned 2024 annual bonuses to Named Executive Officers were accrued at December 31, 2024, and paid in March of 2025. 2024 Equity Awards In 2024, the Named Executive Officers were awarded equity incentives in the form of options and restricted share units (“RSU”). In August of 2024, Mr. Hackman was granted 400,000 options with a strike price of $5.58. In May of 2024, Mr. Raykov was granted 200,000 options with a strike price of $7.12 and 100,000 RSU’s. In March of 2024, Mr. Andrade was granted 100,000 options with a strike price of $7.12 and 50,000 RSU’s. In November of 2024, Mr. Sayad was granted 150,000 options with a strike price of $4.23.

  12. Pay Versus Performance

    Pay Versus Performance As required by Section 953(a) of the Dodd-Frank Wall Street Reform and Consumer Protection Act, and Item 402(v) of Regulation S-K, we are providing the following information about the relationship between executive compensation actually paid and certain financial performance of the Corporation. The following information is presented to disclose the relationship between executive “compensation actually paid” or CAP, as calculated under applicable SEC rules, and the Corporation’s financial performance. As required by SEC rules, the table presented below discloses CAP for (i) the Corporation’s principal executive officer (“PEO”), Mr. Hackman and the former principal executive officer (“Former PEO”) Mr. Raykov, and (ii) the Corporation’s NEOs other than Mr. Hackman and Mr. Raykov (collectively, “Non-PEO NEOs”), on an average basis. The Corporation’s PEO and the Non-PEO NEOs receive time-based RSU awards and their total compensation is not tied to any specific company performance measures.

  13. Pay Versus Performance

    | | | | | | Average | | | | | | | | | | Summary | Average | Value of | | | | | | | | Compensation | Compensation | Initial Fixed $100 | | | | | | | | Total for | Actually Paid to | Investment | Net | | | Summary Compensation Table Total for PEO(1) | | Compensation Actually Paid To PEO(2) | | Non-PEO | Non-PEO | Based On Total | Income | | Year | PEO | Prior PEO | PEO | Prior PEO | NEOs(3) | NEOs(4) | Shareholder Return(5) | (millions)(6) | | (a) | (b) | | (c) | | (d) | (e) | (f) | (g) | | 2024 | 1,611,861 | 3,238,461 | 1,866,208 | 1,960,657 | 1,122,451 | 979,998 | 85 | (436) | | 2023 | | 2,497,849 | | 4,526,511 | 1,234,679 | 2,036,284 | 151 | (16,045) | | 2022 | | 614,161 | | 1,569,464 | 428,919 | 1,197,095 | 129 | (23,714) |

  14. Pay Versus Performance

    | (1) The dollar amounts reported in column (b) are the amounts of total compensation reported for Mr. Hackman, the Corporation’s current Chief Executive Officer (who joined the company in Augus 2024) and Mr. Raykov, the former Chief Executive Officer, for each corresponding year in the “Total” column of the Summary Compensation Table. Refer to “Executive Compensation – Summary Compensation Table.” |

  15. Pay Versus Performance

    | (2) The dollar amounts reported in column (c) represent the amount of CAP as computed in accordance with Item 402(v) of Regulation S-K. The dollar amounts do not reflect the actual amount of compensation earned by or paid to Mr. Hackman and Mr. Raykov during the applicable year as it includes changes in the value of stock compensation for awards which remained unvested at the end of the applicable year. The following table details the applicable adjustments that were made to determine CAP: |

  16. Pay Versus Performance

    The equity award adjustments for each applicable year include the addition (or subtraction, as applicable) of the following:

  17. Pay Versus Performance

    | | | | | | | | Add: Change in | | | | | | | | | | Value as of | | | | | | | | | Add: Change in | Vesting Date | | | | | | Deduct: Stock | Add: Fair Value of | Add: Fair Value of | Fair Value of | of Equity Awards | | | | | Summary | Compensation | of Equity Awards | of Equity Awards | Outstanding and | Granted in | | | | | Compensation | Included | Granted in Fiscal year | Granted and Vested | Unvested Equity | Prior Years | | | | | Table | in Summary | and Unvested | in Fiscal Year | Awards granted | which Vested | Compensation | | Fiscal Year | Executive(s) | Total | Compensation | as of Year-End | | in Prior Fiscal Years | in Fiscal Year | Actually Paid | | | | | (a) | (b) | (c) | (d) | (e) | | | 2024 | PEO | 1,611,861 | 1,386,862 | 1,641,208 | - | - | - | 1,866,208 | | 2024 | Prior PEO | 3,238,461 | 1,606,792 | 632,000 | 679,750 | - | (982,763) | 1,960,657 | | 2024 | Non-PEO NEOs | 1,122,451 | 602,826 | 662,476 | - | (63,392) | (138,710) | 979,998 | | 2023 | Prior PEO | 2,497,849 | 1,655,873 | 2,283,329 | - | (618,750) | 2,019,956 | 4,526,511 | | 2023 | Non-PEO NEOs | 1,234,679 | 856,335 | 1,244,623 | - | (19,094) | 432,411 | 2,036,284 | | 2022 | Prior PEO | 614,161 | - | - | - | (850,186) | 1,805,489 | 1,569,464 | | 2022 | Non-PEO NEOs | 428,919 | - | - | - | (221,690) | 989,866 | 1,197,095 |

  18. Pay Versus Performance

    | (a) The grant date fair value of equity-based awards, as reported in the Summary Compensation Table. |

  19. Pay Versus Performance

    | (b) The year-end fair value of any equity awards granted in the applicable year that are outstanding and unvested as of the end of the year. |

  20. Pay Versus Performance

    | (c) For awards granted and vested in the current fiscal year, the amount equals the fair value at the vesting date. |

  21. Pay Versus Performance

    | (d) The amount of change as of the end of the applicable year (from the end of the prior fiscal year) in fair value of any awards granted in prior years that are outstanding and unvested as of the end of the applicable year. |

  22. Pay Versus Performance

    | (e) For awards granted in prior years that vest in the applicable year, the amount equal to the change as of the vesting date (from the end of the prior fiscal year) in fair value |

  23. Pay Versus Performance

    | (3) The dollar amounts represent the average Summary Compensation Table totals for the non-PEO NEOs. The non-PEO NEOs during the calendar year 2024 were Mr. Andrade, the Corporation’s Chief Financial Officer and effective October 28, 2024, Mr. Sayad, the Corporation’s Chief Medical Officer. The non-PEO NEOs during the calendar year 2023 were Mr. Andrade, the Corporation’s Chief Financial Officer Mr. Haigh, the Corporation’s former Chief Operating Officer, who resigned on June 30, 2024. The Non-PEO NEO during the calendar year 2022 was Mr. Andrade. |

  24. Pay Versus Performance

    | (4) Represents CAP for non-PEO NEOs. The amounts shown do not reflect the actual compensation earned by or paid to the non-PEO NEOs during the applicable year. In accordance with SEC rules, adjustments were made to determine the CAP using the same methodology described in the footnotes above. |

  25. Pay Versus Performance

    | (5) Calculated based upon the closing price of a share of the Corporation’s common stock on the last day of its 2024, 2023, 2022 and fiscal years, which prices were $6.32, $11.22, $9.60, $4.40, respectively. |

  26. Pay Versus Performance

    | (6) Refer to Corporation’s Consolidated Statements of Operations as presented in its Annual Report on Form 10-K filed on March 26, 2025. |

  27. Pay Versus Performance

    Relationship Between Compensation Actually Paid, TSR, and Net Income (Loss) The amounts of CAP shown in the above Pay versus Performance Table have been calculated as required by Item 402(v) of SEC Regulation S-K. Such calculated amounts do not represent the actual amount of compensation earned by or paid to such individuals in the fiscal years shown. Item 402(v) also requires that the Corporation’s total shareholder return (“TSR”) and net income(loss) for each of the fiscal years shown be included in the Pay versus Performance Table as performance measures. While the Compensation Committee considers TSR and net income (loss) in determining executive compensation, the Committee also utilizes various other performance measures in seeking to align executive compensation with the non-PEO NEOs’ performance as well as certain subjective measures, all as described in more detail under “Compensation Discussion and Analysis (CD&A).” The Compensation Committee of the Board of Directors of the Corporation does not have a policy or practice of evaluating cumulative total shareholder return as part of its determination of compensation decisions for Named Executive Officers. As noted in the “Compensation Discussion and Analysis” section of this proxy statement, the Compensation Committee reviews various compensation metrics to ensure the competitiveness of its executive compensation. The Compensation Committee determines on an annual basis the relevant objectives and goals that drive each of the Named Executive Officer’s compensation. While the Corporation’s financial condition and share price are measurements that the Corporation utilizes in evaluating the relevant objectives, the Compensation Committee also considers the advancement of the Corporation’s product candidates, both preclinical and clinical, as well as the achievement of corporative objectives, including financings, partnerships and other business development.

  28. Summary Compensation Table

    Summary Compensation Table The following table sets out certain information respecting the compensation paid to our Chief Executive Officer, our Chief Financial Officer and Chief Medical Officer (collectively, “Named Executive Officers”) for the fiscal years ended December 31, 2024 and December 31, 2023.

  29. Summary Compensation Table

    | | | | | Restricted Share | Option | | | | Name and Principal Position | Year | Salary ($) | Bonus ($) | Unit Awards ($) | Awards ($) (1) | Other ($) (2) | Total ($) | | Jeff Hackman, CEO | 2024 | 225,000 | — | — | 1,386,862 | — | 1,611,862 | | | 2023 | — | — | — | — | — | — | | Rostislav Raykov, former CEO | 2024 | 411,643 | 611,339 | 712,000 | 894,792 | 608,687 | 3,238,461 | | | 2023 | 607,062 | 278,006 | 728,000 | 927,873 | — | 2,540,941 | | Robert Andrade, CFO | 2024 | 463,553 | 494,446 | 356,000 | 447,396 | — | 1,761,395 | | | 2023 | 439,764 | 161,113 | 312,000 | 397,660 | — | 1,310,537 | | Pierre Sayad, CMO | 2024 | 81,250 | — | — | 402,256 | — | 483,506 | | | 2023 | — | — | — | — | — | — |

  30. Summary Compensation Table

    | (1) Represents the aggregate grant date fair value computed in accordance with FASB ASC Topic 718. Dollar value amounts are based on individual grants to each of Mr. Hackman, Mr. Raykov, Mr. Andrade, and Mr. Sayad of 400,000, 200,000, 100,000, and 150,000 options, respectively. Such option grants were received on August 15, 2024, for Mr. Hackman, May 16, 2024, for M r. Raykov, Mr. Andrade and November 13 for Mr. Sayad. The August grant has a strike price of $5.58, the May grants have a strike price of $7.12 and the November grant has a strike price of $4.23. On May 16, 2024, Mr. Raykov and Mr. Andrade were also awarded 100,000 and 50,000 Restricted Share Units each, respectively. All option grants expire 10 years after the grant date. All equity awards vest in the following manner: one-third of these options shall vest and may be exercised one year after the grant date (the “Vesting Commencement Date”). The remaining two-thirds of the options shall vest monthly at a rate of 1/24th of the remaining grant and shall be exercisable as of the last day of each following month after the Vesting Commencement Date. As of the third anniversary of the grant date, all of the options shall be vested. Mr. Raykov resigned as the CEO of the Corporation in August of 2024. Upon separation, all of Mr. Raykov’s options became fully vested. His RSU’s remain on the original vesting schedule as awarded. |

  31. Summary Compensation Table

    | (2) Represents severance payment in accordance with Mr. Raykov’s separation agreement. |

  32. Summary Compensation Table

    Jeff Hackman Mr. Hackman has been employed by us since August 2024. Pursuant to an employment agreement dated August 5, 2024 between Mr. Hackman and Fennec, Mr. Hackman is employed as our Chief Executive officer and: (a) received an initial salary of $550,000, subject to annual adjustment by our Board of Directors, (b) may receive annual bonuses at the sole discretion of the Board. If Mr. Hackman’s employment terminates due to a change of control of Fennec, Mr. Hackman’s remaining unvested equity shall immediately vest and be fully exercisable. If Mr. Hackman is dismissed from employment by us for any reason other than “for cause,” we are obligated to pay Mr. Hackman severance compensation equal to twelve months of salary. The initial term of the agreement was for one year and the agreement automatically extends for additional one-year periods unless terminated by either party in accordance with the agreement. Effective March 1, 2025, Mr. Hackman’s salary is $559,167 per year. Rostislav Raykov Mr. Raykov was employed by us from July 2009 until August 2024. Pursuant to an employment agreement dated May 3, 2010 between Mr. Raykov and Fennec, Mr. Raykov was employed as our Chief Executive Officer and: (a) received an initial annual salary in the amount of $140,000, subject to annual adjustment by our Board of Directors, (b) upon approval by shareholders of our amended stock option plan was granted options to purchase up to 5.0% of our common shares estimated by us to be outstanding upon completion of our 2010 rights offering, and (c) was entitled to receive annual bonuses at the sole discretion of the Board. If Mr. Raykov’s employment terminates due to a change of control of Fennec, Mr. Raykov’s remaining unvested equity shall immediately vest and be fully exercisable. If Mr. Raykov is dismissed from employment by us for any reason other than “for cause,” we were obligated to pay Mr. Raykov severance compensation equal to twelve months of salary. The initial term of the agreement was for one year and the agreement automatically extended for additional one-year periods unless terminated by either party in accordance with the agreement. Effective December 31, 2023, Mr. Raykov’s salary was $585,276 per year. Mr. Raykov resigned as CEO in August of 2024. Upon separation, all of Mr. Raykov’s options became fully vested. His RSUs remain on the original vesting schedule as awarded.

  33. Payments on Termination

    Payments on Termination The following table provides details regarding the estimated incremental payments from us to each of the Named Executive Officers assuming termination without cause on December 31, 2024.

  34. Payments on Termination

    | Name | Severance | Estimated Bonus | Value of benefits | | Jeff Hackman, CEO | $550,000 | $275,000 | $825,000 | | Robert Andrade, CFO | $347,664 | $161,113 | $508,777 | | Pierre Sayad, CMO | $337,500 | $135,000 | $472,500 |

  35. Compensation of Directors

    Compensation of Directors

  36. Director Compensation Table

    Director Compensation Table The following table summarizes the compensation earned by our non-executive directors for the year ended December 31, 2024.

  37. Director Compensation Table

    | Name | Fees paid in Cash | Stock Awards | Option Awards(1)(3) | Total | | Mr. Raykov(2) | — | — | — | — | | Dr. Islam | 100,000 | — | 82,061 | 182,061 | | Dr. Brughera | 77,500 | — | 65,649 | 143,149 | | Dr. Cook | 62,500 | — | 65,649 | 128,149 | | Mr. Rallis | 82,500 | — | 65,649 | 148,149 | | Total | $322,500 | $— | $279,009 | $601,509 |

  38. Director Compensation Table

    | (1) Represents the aggregate grant date fair value computed in accordance with FASB ASC Topic 718. |

  39. Director Compensation Table

    | (2) Mr. Raykov become a non-executive director effective upon his resignation as CEO in August 2024. Includes only compensation, if any, received in his capacity as director and excludes compensation received by Mr. Raykov as CEO. |

  40. Director Compensation Table

    | (3) Detail of grants are presented in the following table: |

  41. Director Compensation Table

    | | | | Option Exercise Price | | Name | Date of Grant | Number of Options Granted | $USD | | Mr. Rallis | August 15, 2024 | 20,000 | 5.58 | | Dr. Brughera | August 15, 2024 | 20,000 | 5.58 | | Mr. Raykov(1) | August 15, 2024 | 20,000 | 5.58 | | Dr. Islam | August 15, 2024 | 25,000 | 5.58 | | Dr. Cook | August 15, 2024 | 20,000 | 5.58 | | Total | | 105,000 | |

  42. Director Compensation Table

    | (1) Mr. Raykov become a non-executive director upon his resignation as CEO in August of 2024. Includes only compensation, if any, received in his capacity as director and excludes compensation received by Mr. Raykov as CEO. |

  43. Director Compensation Table

    The annual compensation considerations for non-executive directors also include the awarding of stock options. We believe that granting of options to the non-executive directors serves three primary purposes: (1) to recognize the significant time and effort commitments of being a member of our Board; (2) to provide long-term incentives for future efforts since the value of the options is directly dependent on our market valuation; and (3) to retain quality individuals. When determining whether and how many new option grants will be made, the Compensation Committee takes into account the amount and terms of any outstanding options. We do not require our non-executive directors to own a specific amount of our common shares. Each of current directors Khalid Islam, Marco Brughera, Jodi Cook, Rosty Raykov and Chris A. Rallis has entered into an Independent Director Agreement with the Corporation, which provides for cash compensation as set forth by the Compensation Committee commensurate with that member’s responsibilities. The Compensation Committee may also remunerate members in the form of a grant of options to purchase shares of our common shares. The options immediately vest when granted and are otherwise subject to the terms and conditions of our stock option plan, as amended. The Independent Director Agreements also provide for the reimbursement of such director’s reasonable travel and related expenses incurred in the course of attending board meetings.

  44. Non-Executive Director Outstanding Equity Awards at December 31, 2024

    Non-Executive Director Outstanding Equity Awards at December 31, 2024

  45. Non-Executive Director Outstanding Equity Awards at December 31, 2024

    | | | | | Value of | | | Number of Securities | | Option | Unexercised in | | | Underlying Unexercised | Option | Expiration | the-Money | | Name | Options (#) Exercisable | Exercise Price (USD$) | Date | Options (USD$)(1) | | Rosty Raykov | —(2) | — | — | — | | Chris Rallis | 1,992 | 2.51 | 03/16/2025 | 17,350 | | | 2,173 | 2.30 | 05/11/2025 | 19,383 | | | 2,127 | 2.35 | 08/03/2025 | 18,866 | | | 4,062 | 1.23 | 11/10/2025 | 40,579 | | | 4,098 | 2.44 | 06/09/2026 | 35,980 | | | 10,246 | 2.44 | 06/09/2026 | 89,960 | | | 20,000 | 5.10 | 06/27/2027 | 122,400 | | | 20,000 | 10.93 | 06/08/2028 | 5,800 | | | 20,000 | 4.26 | 06/18/2029 | 139,200 | | | 20,000 | 6.17 | 08/13/2030 | 101,000 | | | 20,000 | 7.52 | 06/29/2031 | 74,000 | | | 20,000 | 5.59 | 06/14/2032 | 112,600 | | Dr. Khalid Islam | 25,000 | 5.10 | 06/27/2027 | 153,000 | | | 25,000 | 10.93 | 06/08/2028 | 7,250 | | | 25,000 | 4.26 | 06/18/2029 | 174,000 | | | 25,000 | 6.17 | 08/13/2030 | 126,250 | | | 25,000 | 7.52 | 06/29/2031 | 92,500 | | | 25,000 | 5.59 | 06/14/2032 | 140,750 | | | 25,000 | 8.78 | 06/12/2024 | 61,000 | | Dr. Marco Brughera | 35,545 | 2.11 | 12/30/2026 | 323,815 | | | 20,000 | 5.10 | 06/27/2027 | 122,400 | | | 20,000 | 10.93 | 06/08/2028 | 5,800 | | | 20,000 | 4.26 | 06/18/2029 | 139,200 | | | 20,000 | 6.17 | 08/13/2030 | 101,000 | | | 20,000 | 7.52 | 06/29/2031 | 74,000 | | | 20,000 | 5.59 | 06/14/2032 | 112,600 | | | 20,000 | 8.78 | 06/12/2024 | 48,800 | | Dr. Jodi Cook | 20,000 | 5.40 | 11/13/2029 | 116,400 | | | 20,000 | 6.17 | 08/13/2030 | 101,000 | | | 20,000 | 7.52 | 06/29/2031 | 74,000 | | | 20,000 | 5.59 | 06/14/2032 | 112,600 |

  46. Non-Executive Director Outstanding Equity Awards at December 31, 2024

    | (1) Calculated using the closing price of our Common Share on December 31, 2024 USD$6.32 on the Nasdaq which was the last trading day for the year 2024. |

  47. Non-Executive Director Outstanding Equity Awards at December 31, 2024

    | (2) Awards listed for Mr. Raykov only include awards he received in his capacity as director (not as CEO). |

  48. Indebtedness of Directors and Executive Officers

    Indebtedness of Directors and Executive Officers Section 13(k) of the Exchange Act prohibits Fennec from making or arranging an extension of credit to its directors or executive officers in the form of a personal loan. No individual, who is or was a director, executive officer or employee of Fennec, nor any proposed nominee for election as a director of Fennec, nor any associate of any one of them: (i) is or, at any time since the beginning of Fennec’s most recent completed financial period, has been indebted to Fennec or any of its subsidiaries; or (ii) was indebted to another entity, which indebtedness is, or was at any time during Fennec’s most recent completed financial period, the subject of a guarantee, support agreement, letter of credit or other similar arrangement or understanding provided by Fennec or any of its subsidiaries.

  49. Board of Directors

    Board of Directors The Board of Directors is composed of a majority of independent directors. The Board applies the definition of independence found in Canadian National Instrument 58-101 and National Policy 58-201 and the applicable rules of Nasdaq. The Board has determined that four of the current six directors are “independent”, being Dr. Cook and Messrs. Rallis, Brughera and Islam. Two directors have a material relationship with the Corporation and therefore are not independent. Mr. Raykov, the former Chief Executive Officer of the Corporation, and Mr. Hackman, the current Chief Executive Officer, are considered to have a material relationship with the Corporation by virtue of his executive officer position. Fennec is of the view that the composition of its Board reflects a diversity of background and experience that are important for effective corporate governance. Other directorships held by Board members are described in this Circular under the heading “Ordinary Matters – Election of Directors.” During the financial year ended December 31, 2024, the Board devoted a portion of ten meetings to discuss in the absence of directors who are not “independent,” and certain of the Committees also conducted executive sessions where all participants were independent directors. In order to facilitate open and candid discussion among its independent directors, the Corporate Governance Guidelines provide that independent directors should meet at least annually without the presence of management or non-independent directors, that the Chairman or Lead Independent Director is authorized to call additional meetings of the independent directors and that the Chairman or Lead Independent Director is authorized to act as the presiding director at such meetings and to develop the agenda for such meetings. In addition, each Board member is free to suggest the inclusion of items on any Board or Committee meeting agenda and suggest pre-meeting materials to either the Chair of the Board or the Lead Independent Director. At any meeting of the Board, each Board member is also free to raise subjects that are not on the agenda for that meeting. Furthermore, each Board committee, the Chairman and the Lead Independent Director, on behalf of the independent directors as a group, have the authority to hire legal, accounting, financial or other advisors as they may deem necessary in their best judgment, without the need to obtain the prior approval of any officer of the Corporation. The Chief Financial Officer of the Corporation will arrange for payment of the invoices of any such third party. Directors’ Attendance For the fiscal year ended December 31, 2024, the Board met on ten occasions, the Audit Committee met on five occasions, the Compensation Committee met on seven occasions, and the Governance and Nominating Committee met on three occasions. The following table sets forth the attendance of directors at meetings of the Board and Committee meetings.

  50. Board of Directors

    | | | | | Attendance at | | | | Attendance at | Attendance at | Governance/ | | | | Audit | Compensation | Nominating | | | Attendance at | Committee | Committee | Committee | | Director | Board Meetings | Meetings | Meetings | Meetings | | Jeff Hackman | 2/2 | — | — | — | | Chris Rallis | 10/10 | 4/4 | 6/6 | 3/3 | | Dr. Khalid Islam | 10/10 | 4/4 | — | — | | Dr. Marco Brughera | 10/10 | 4/4 | 6/6 | 3/3 | | Dr. Jodi Cook | 10/10 | — | 6/6 | 3/3 | | Rostislav Raykov | 10/10 | — | — | — |

  51. Board of Directors

    The Board expects management to be responsible for the day-to-day operations of and to implement the approved strategic business plan within the context of authorized budgets and corporate policies and procedures. Management is expected to report regularly to the Board in a comprehensive, accurate, and timely fashion on Fennec’s business and affairs. Fennec does not have a formal written policy regarding attendance of Board members at annual meetings of the shareholders. Fennec, however, strongly encourages all directors to attend such meetings.